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“…Compared to the diploid parental line, the frequencies of chromosome missegregation and micronuclei formation were significantly elevated in most PTA clones (Figure 2A) but not in the tetraploid line (Figure 2A). In agreement with previous work (Nicholson et al , 2015), the trisomic clones showed similar aberrations, albeit to a lesser extent (Supplemental Figure S2B). Furthermore, we observed an increase of structural aberrations in PTA lines and, consistent with earlier work (Kuznetsova et al 2015; Passerini et al, 2016) also in trisomic clones (Figure 2B).…”
Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability Christina Viganó, et al. 2018 Molecular Biology of the Cell Section: Results